Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region.
Identifieur interne : 000778 ( Main/Exploration ); précédent : 000777; suivant : 000779Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region.
Auteurs : Efrain Alday [Mexique] ; Dora Valencia [Mexique] ; Adriana Garibay-Escobar [Mexique] ; Zaira Domínguez-Esquivel [Mexique] ; Anna Lisa Piccinelli [Italie] ; Luca Rastrelli [Italie] ; Juan Monribot-Villanueva [Mexique] ; José A. Guerrero-Analco [Mexique] ; Ram N Enrique Robles-Zepeda [Mexique] ; Javier Hernandez [Mexique] ; Carlos Velazquez [Mexique]Source :
- Die Naturwissenschaften [ 1432-1904 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- composition chimique : Populus, Propolis.
- effets des médicaments et des substances chimiques : Prolifération cellulaire.
- pharmacologie : Propolis.
- Cellules A549, Cellules HeLa, Climat désertique, Humains, Lignée cellulaire tumorale.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Propolis.
- chemistry : Populus.
- drug effects : Cell Proliferation.
- chemical , pharmacology : Propolis.
- A549 Cells, Cell Line, Tumor, Desert Climate, HeLa Cells, Humans.
Abstract
The main chemical composition of Sonoran propolis (SP), as well as its antiproliferative activity on cancer cells through apoptosis induction, has been reported. The chemical constitution of SP remained qualitatively similar throughout the year, whereas the antiproliferative effect on cancer cells exhibited significant differences amongst seasonal samples. The main goal of this study was to provide phytochemical and pharmacological evidence for the botanical source of SP and its antiproliferative constituents. A chemical comparative analysis of SP and plant resins of species found in the surrounding areas of the beehives was carried out by HPLC-UV-DAD, as well as by 1H NMR experiments. The antiproliferative activity on cancerous (M12.C3.F6, HeLa, A549, PC-3) and normal cell lines (L-929; ARPE-19) was assessed through MTT assays. Here, the main polyphenolic profile of SP resulted to be qualitatively similar to Populus fremontii resins (PFR). However, the antiproliferative activity of PFR on cancer cells did not consistently match that exhibited by SP throughout the year. Additionally, SP induced morphological modifications on treated cells characterised by elongation, similar to those induced by colchicine, and different to those observed with PFR treatment. These results suggest that P. fremontii is the main botanical source of SP along the year. Nevertheless, the antiproliferative constituents of SP that induce that characteristic morphological elongation on treated cells are not obtained from PFR. Moreover, the presence of kaempferol-3-methyl-ether in SP could point Ambrosia ambrosioides as a secondary plant source. In conclusion, SP is a bioactive poplar-type propolis from semi-arid zones, in which chemical compounds derived from other semi-arid plant sources than poplar contribute to its antiproliferative activity.
DOI: 10.1007/s00114-019-1620-2
PubMed: 31069518
Affiliations:
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Guerrero-Analco</name><affiliation wicri:level="1"><nlm:affiliation>Red de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL) A.C., Clúster Científico y Tecnológico Biomimic®, Carretera antigua a Coatepec 351, 91070, Xalapa, Veracruz, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Red de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL) A.C., Clúster Científico y Tecnológico Biomimic®, Carretera antigua a Coatepec 351, 91070, Xalapa, Veracruz</wicri:regionArea><wicri:noRegion>Veracruz</wicri:noRegion></affiliation></author><author><name sortKey="Robles Zepeda, Ram N Enrique" sort="Robles Zepeda, Ram N Enrique" uniqKey="Robles Zepeda R" first="Ram N Enrique" last="Robles-Zepeda">Ram N Enrique Robles-Zepeda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora</wicri:regionArea><wicri:noRegion>Sonora</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez, Javier" sort="Hernandez, Javier" uniqKey="Hernandez J" first="Javier" last="Hernandez">Javier Hernandez</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Química de productos Naturales, Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Dr. Luis Castelazo Ayala S/N, 575, 91190, Xalapa, Veracruz, Mexico. javmartinez@uv.mx.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Química de productos Naturales, Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Dr. Luis Castelazo Ayala S/N, 575, 91190, Xalapa, Veracruz</wicri:regionArea><wicri:noRegion>Veracruz</wicri:noRegion></affiliation></author><author><name sortKey="Velazquez, Carlos" sort="Velazquez, Carlos" uniqKey="Velazquez C" first="Carlos" last="Velazquez">Carlos Velazquez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico. velaz@guayacan.uson.mx.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora</wicri:regionArea><wicri:noRegion>Sonora</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31069518</idno><idno type="pmid">31069518</idno><idno type="doi">10.1007/s00114-019-1620-2</idno><idno type="wicri:Area/Main/Corpus">000911</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000911</idno><idno type="wicri:Area/Main/Curation">000911</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000911</idno><idno type="wicri:Area/Main/Exploration">000911</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region.</title><author><name sortKey="Alday, Efrain" sort="Alday, Efrain" uniqKey="Alday E" first="Efrain" last="Alday">Efrain Alday</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora</wicri:regionArea><wicri:noRegion>Sonora</wicri:noRegion></affiliation></author><author><name sortKey="Valencia, Dora" sort="Valencia, Dora" uniqKey="Valencia D" first="Dora" last="Valencia">Dora Valencia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Av. Universidad e Irigoyen, 83600, Caborca, Son., Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Av. Universidad e Irigoyen, 83600, Caborca, Son.</wicri:regionArea><wicri:noRegion>Son.</wicri:noRegion></affiliation></author><author><name sortKey="Garibay Escobar, Adriana" sort="Garibay Escobar, Adriana" uniqKey="Garibay Escobar A" first="Adriana" last="Garibay-Escobar">Adriana Garibay-Escobar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora</wicri:regionArea><wicri:noRegion>Sonora</wicri:noRegion></affiliation></author><author><name sortKey="Dominguez Esquivel, Zaira" sort="Dominguez Esquivel, Zaira" uniqKey="Dominguez Esquivel Z" first="Zaira" last="Domínguez-Esquivel">Zaira Domínguez-Esquivel</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Química de productos Naturales, Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Dr. Luis Castelazo Ayala S/N, 575, 91190, Xalapa, Veracruz, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Química de productos Naturales, Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Dr. Luis Castelazo Ayala S/N, 575, 91190, Xalapa, Veracruz</wicri:regionArea><wicri:noRegion>Veracruz</wicri:noRegion></affiliation></author><author><name sortKey="Piccinelli, Anna Lisa" sort="Piccinelli, Anna Lisa" uniqKey="Piccinelli A" first="Anna Lisa" last="Piccinelli">Anna Lisa Piccinelli</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, SA, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Rastrelli, Luca" sort="Rastrelli, Luca" uniqKey="Rastrelli L" first="Luca" last="Rastrelli">Luca Rastrelli</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, SA, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Monribot Villanueva, Juan" sort="Monribot Villanueva, Juan" uniqKey="Monribot Villanueva J" first="Juan" last="Monribot-Villanueva">Juan Monribot-Villanueva</name><affiliation wicri:level="1"><nlm:affiliation>Red de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL) A.C., Clúster Científico y Tecnológico Biomimic®, Carretera antigua a Coatepec 351, 91070, Xalapa, Veracruz, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Red de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL) A.C., Clúster Científico y Tecnológico Biomimic®, Carretera antigua a Coatepec 351, 91070, Xalapa, Veracruz</wicri:regionArea><wicri:noRegion>Veracruz</wicri:noRegion></affiliation></author><author><name sortKey="Guerrero Analco, Jose A" sort="Guerrero Analco, Jose A" uniqKey="Guerrero Analco J" first="José A" last="Guerrero-Analco">José A. Guerrero-Analco</name><affiliation wicri:level="1"><nlm:affiliation>Red de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL) A.C., Clúster Científico y Tecnológico Biomimic®, Carretera antigua a Coatepec 351, 91070, Xalapa, Veracruz, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Red de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL) A.C., Clúster Científico y Tecnológico Biomimic®, Carretera antigua a Coatepec 351, 91070, Xalapa, Veracruz</wicri:regionArea><wicri:noRegion>Veracruz</wicri:noRegion></affiliation></author><author><name sortKey="Robles Zepeda, Ram N Enrique" sort="Robles Zepeda, Ram N Enrique" uniqKey="Robles Zepeda R" first="Ram N Enrique" last="Robles-Zepeda">Ram N Enrique Robles-Zepeda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora</wicri:regionArea><wicri:noRegion>Sonora</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez, Javier" sort="Hernandez, Javier" uniqKey="Hernandez J" first="Javier" last="Hernandez">Javier Hernandez</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Química de productos Naturales, Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Dr. Luis Castelazo Ayala S/N, 575, 91190, Xalapa, Veracruz, Mexico. javmartinez@uv.mx.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Química de productos Naturales, Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Dr. Luis Castelazo Ayala S/N, 575, 91190, Xalapa, Veracruz</wicri:regionArea><wicri:noRegion>Veracruz</wicri:noRegion></affiliation></author><author><name sortKey="Velazquez, Carlos" sort="Velazquez, Carlos" uniqKey="Velazquez C" first="Carlos" last="Velazquez">Carlos Velazquez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico. velaz@guayacan.uson.mx.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora</wicri:regionArea><wicri:noRegion>Sonora</wicri:noRegion></affiliation></author></analytic><series><title level="j">Die Naturwissenschaften</title><idno type="eISSN">1432-1904</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells (MeSH)</term><term>Cell Line, Tumor (MeSH)</term><term>Cell Proliferation (drug effects)</term><term>Desert Climate (MeSH)</term><term>HeLa Cells (MeSH)</term><term>Humans (MeSH)</term><term>Populus (chemistry)</term><term>Propolis (chemistry)</term><term>Propolis (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules A549 (MeSH)</term><term>Cellules HeLa (MeSH)</term><term>Climat désertique (MeSH)</term><term>Humains (MeSH)</term><term>Lignée cellulaire tumorale (MeSH)</term><term>Populus (composition chimique)</term><term>Prolifération cellulaire (effets des médicaments et des substances chimiques)</term><term>Propolis (composition chimique)</term><term>Propolis (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Propolis</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Populus</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Populus</term><term>Propolis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Prolifération cellulaire</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Propolis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Propolis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Cell Line, Tumor</term><term>Desert Climate</term><term>HeLa Cells</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules A549</term><term>Cellules HeLa</term><term>Climat désertique</term><term>Humains</term><term>Lignée cellulaire tumorale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The main chemical composition of Sonoran propolis (SP), as well as its antiproliferative activity on cancer cells through apoptosis induction, has been reported. The chemical constitution of SP remained qualitatively similar throughout the year, whereas the antiproliferative effect on cancer cells exhibited significant differences amongst seasonal samples. The main goal of this study was to provide phytochemical and pharmacological evidence for the botanical source of SP and its antiproliferative constituents. A chemical comparative analysis of SP and plant resins of species found in the surrounding areas of the beehives was carried out by HPLC-UV-DAD, as well as by <sup>1</sup>H NMR experiments. The antiproliferative activity on cancerous (M12.C3.F6, HeLa, A549, PC-3) and normal cell lines (L-929; ARPE-19) was assessed through MTT assays. Here, the main polyphenolic profile of SP resulted to be qualitatively similar to Populus fremontii resins (PFR). However, the antiproliferative activity of PFR on cancer cells did not consistently match that exhibited by SP throughout the year. Additionally, SP induced morphological modifications on treated cells characterised by elongation, similar to those induced by colchicine, and different to those observed with PFR treatment. These results suggest that P. fremontii is the main botanical source of SP along the year. Nevertheless, the antiproliferative constituents of SP that induce that characteristic morphological elongation on treated cells are not obtained from PFR. Moreover, the presence of kaempferol-3-methyl-ether in SP could point Ambrosia ambrosioides as a secondary plant source. In conclusion, SP is a bioactive poplar-type propolis from semi-arid zones, in which chemical compounds derived from other semi-arid plant sources than poplar contribute to its antiproliferative activity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31069518</PMID><DateCompleted><Year>2019</Year><Month>05</Month><Day>22</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1432-1904</ISSN><JournalIssue CitedMedium="Internet"><Volume>106</Volume><Issue>5-6</Issue><PubDate><Year>2019</Year><Month>May</Month><Day>08</Day></PubDate></JournalIssue><Title>Die Naturwissenschaften</Title><ISOAbbreviation>Naturwissenschaften</ISOAbbreviation></Journal><ArticleTitle>Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region.</ArticleTitle><Pagination><MedlinePgn>25</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00114-019-1620-2</ELocationID><Abstract><AbstractText>The main chemical composition of Sonoran propolis (SP), as well as its antiproliferative activity on cancer cells through apoptosis induction, has been reported. The chemical constitution of SP remained qualitatively similar throughout the year, whereas the antiproliferative effect on cancer cells exhibited significant differences amongst seasonal samples. The main goal of this study was to provide phytochemical and pharmacological evidence for the botanical source of SP and its antiproliferative constituents. A chemical comparative analysis of SP and plant resins of species found in the surrounding areas of the beehives was carried out by HPLC-UV-DAD, as well as by <sup>1</sup>H NMR experiments. The antiproliferative activity on cancerous (M12.C3.F6, HeLa, A549, PC-3) and normal cell lines (L-929; ARPE-19) was assessed through MTT assays. Here, the main polyphenolic profile of SP resulted to be qualitatively similar to Populus fremontii resins (PFR). However, the antiproliferative activity of PFR on cancer cells did not consistently match that exhibited by SP throughout the year. Additionally, SP induced morphological modifications on treated cells characterised by elongation, similar to those induced by colchicine, and different to those observed with PFR treatment. These results suggest that P. fremontii is the main botanical source of SP along the year. Nevertheless, the antiproliferative constituents of SP that induce that characteristic morphological elongation on treated cells are not obtained from PFR. Moreover, the presence of kaempferol-3-methyl-ether in SP could point Ambrosia ambrosioides as a secondary plant source. In conclusion, SP is a bioactive poplar-type propolis from semi-arid zones, in which chemical compounds derived from other semi-arid plant sources than poplar contribute to its antiproliferative activity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alday</LastName><ForeName>Efrain</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valencia</LastName><ForeName>Dora</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Av. Universidad e Irigoyen, 83600, Caborca, Son., Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garibay-Escobar</LastName><ForeName>Adriana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Domínguez-Esquivel</LastName><ForeName>Zaira</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Laboratorio de Química de productos Naturales, Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Dr. Luis Castelazo Ayala S/N, 575, 91190, Xalapa, Veracruz, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piccinelli</LastName><ForeName>Anna Lisa</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, SA, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rastrelli</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, SA, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monribot-Villanueva</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Red de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL) A.C., Clúster Científico y Tecnológico Biomimic®, Carretera antigua a Coatepec 351, 91070, Xalapa, Veracruz, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerrero-Analco</LastName><ForeName>José A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Red de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL) A.C., Clúster Científico y Tecnológico Biomimic®, Carretera antigua a Coatepec 351, 91070, Xalapa, Veracruz, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robles-Zepeda</LastName><ForeName>Ramón Enrique</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernandez</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratorio de Química de productos Naturales, Unidad de Servicios de Apoyo en Resolución Analítica, Universidad Veracruzana, Dr. Luis Castelazo Ayala S/N, 575, 91190, Xalapa, Veracruz, Mexico. javmartinez@uv.mx.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Velazquez</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3728-7848</Identifier><AffiliationInfo><Affiliation>Department of Chemistry-Biology, University of Sonora, Blvd. Luis Encinas y Rosales s/n, 83000, Hermosillo, Sonora, Mexico. velaz@guayacan.uson.mx.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>05</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Naturwissenschaften</MedlineTA><NlmUniqueID>0400767</NlmUniqueID><ISSNLinking>0028-1042</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9009-62-5</RegistryNumber><NameOfSubstance UI="D011429">Propolis</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000072283" MajorTopicYN="N">A549 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003889" MajorTopicYN="N">Desert Climate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011429" MajorTopicYN="N">Propolis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ambrosia ambrosioides (Cav.) Payne</Keyword><Keyword MajorTopicYN="N">Antiproliferative activity</Keyword><Keyword MajorTopicYN="N">Polyphenolic profile</Keyword><Keyword MajorTopicYN="N">Populus fremontii S. Watson</Keyword><Keyword MajorTopicYN="N">Sonoran Desert propolis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>01</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>04</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>04</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>5</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31069518</ArticleId><ArticleId IdType="doi">10.1007/s00114-019-1620-2</ArticleId><ArticleId 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IdType="pubmed">9651052</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Italie</li><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Alday, Efrain" sort="Alday, Efrain" uniqKey="Alday E" first="Efrain" last="Alday">Efrain Alday</name></noRegion><name sortKey="Dominguez Esquivel, Zaira" sort="Dominguez Esquivel, Zaira" uniqKey="Dominguez Esquivel Z" first="Zaira" last="Domínguez-Esquivel">Zaira Domínguez-Esquivel</name><name sortKey="Garibay Escobar, Adriana" sort="Garibay Escobar, Adriana" uniqKey="Garibay Escobar A" first="Adriana" last="Garibay-Escobar">Adriana Garibay-Escobar</name><name sortKey="Guerrero Analco, Jose A" sort="Guerrero Analco, Jose A" uniqKey="Guerrero Analco J" first="José A" last="Guerrero-Analco">José A. Guerrero-Analco</name><name sortKey="Hernandez, Javier" sort="Hernandez, Javier" uniqKey="Hernandez J" first="Javier" last="Hernandez">Javier Hernandez</name><name sortKey="Monribot Villanueva, Juan" sort="Monribot Villanueva, Juan" uniqKey="Monribot Villanueva J" first="Juan" last="Monribot-Villanueva">Juan Monribot-Villanueva</name><name sortKey="Robles Zepeda, Ram N Enrique" sort="Robles Zepeda, Ram N Enrique" uniqKey="Robles Zepeda R" first="Ram N Enrique" last="Robles-Zepeda">Ram N Enrique Robles-Zepeda</name><name sortKey="Valencia, Dora" sort="Valencia, Dora" uniqKey="Valencia D" first="Dora" last="Valencia">Dora Valencia</name><name sortKey="Velazquez, Carlos" sort="Velazquez, Carlos" uniqKey="Velazquez C" first="Carlos" last="Velazquez">Carlos Velazquez</name></country><country name="Italie"><noRegion><name sortKey="Piccinelli, Anna Lisa" sort="Piccinelli, Anna Lisa" uniqKey="Piccinelli A" first="Anna Lisa" last="Piccinelli">Anna Lisa Piccinelli</name></noRegion><name sortKey="Rastrelli, Luca" sort="Rastrelli, Luca" uniqKey="Rastrelli L" first="Luca" last="Rastrelli">Luca Rastrelli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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